hrp0097p1-449 | Fat, Metabolism and Obesity | ESPE2023

Body composition following initiation of daily glucocorticoid in Duchenne Muscular Dystrophy: Identifying the timing of increase of fat mass to introduce intensive weight management strategies

McQuillan Erin , Dunne Jennifer , Mochrie Rachel , Horrocks Iain , Joseph Shuko , Choong Wong Sze

Background: Glucocorticoid (GC) therapy is standard of care of management of Duchenne Muscular Dystrophy (DMD) but its use is associated with a range of side-effects. Weight gain leading to significant obesity is common in GC treated boys. There are limited studies evaluating body composition in DMD following initiation of GC, and the timing of increase in fat mass is not known.Aim(s): To evaluate changes in growth param...